2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126436D
    Poly-L-ornithine hydrochloride (MW 15000-30000) 26982-21-8
    Poly-L-ornithine hydrochloride (MW 15000-30000) is a polycationic homopolymer composed of L-ornithine. Poly-L-ornithine hydrochloride (MW 15000-30000) adsorbs negatively charged species through electrostatic interactions. Poly-L-ornithine hydrochloride (MW 15000-30000) can be used as a key component of polyelectrolyte complexes to construct core-shell structure carriers to achieve controlled delivery of growth factors (such as rhBMP-2, FGF-1). Poly-L-ornithine hydrochloride (MW 15000-30000) is used in the study of diabetes and bone regeneration related diseases.
    Poly-L-ornithine hydrochloride (MW 15000-30000)
  • HY-B1829AR
    Dexamethasone phosphate disodium (Standard) 2392-39-4 99.88%
    Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium (Standard) is the analytical standard of Dexamethasone phosphate disodium (HY-B1829A). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).
    Dexamethasone phosphate disodium (Standard)
  • HY-N0215S2
    L-Phenylalanine-13C 81201-86-7 99.66%
    L-Phenylalanine-13C is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-13C
  • HY-P990201
    Anti-Mouse L-Selectin/CD62L Antibody (Mel-14)
    Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) is an anti-mouse L-Selectin/CD62L IgG2a monoclonal antibody. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can significantly inhibit the migration of T cells and B cells. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can block initial lymphocyte homing. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can be used for researches on inflammation, metabolic and infection conditions such as diabetes and parasitic infections.
    Anti-Mouse L-Selectin/CD62L Antibody (Mel-14)
  • HY-W016187
    2-(Naphthalen-2-yl)acetic acid 581-96-4 99.90%
    2-(Naphthalen-2-yl)acetic acid (2-Naphthylacetic acid) is a plant growth regulator that can improve the quality and yield of crops such as bean sprouts. In addition, 2-(Naphthalen-2-yl)acetic acid can be used as a probe to study the distribution of amino acid conjugation mechanisms in different species.
    2-(Naphthalen-2-yl)acetic acid
  • HY-W251393
    S-(2-Carboxypropyl)-L-cysteine 6852-42-2
    S-(2-Carboxypropyl)-L-cysteine (β-Isobuteine) is a urine metabolite, a metabolic marker of leigh-like syndrome.
    S-(2-Carboxypropyl)-L-cysteine
  • HY-W339331
    Flubendiamide 272451-65-7 ≥98.0%
    Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis.
    Flubendiamide
  • HY-W414548
    7α,27-Dihydroxycholesterol 4725-24-0 99.93%
    7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).
    7α,27-Dihydroxycholesterol
  • HY-W590669
    C16-Dihydroceramide 5966-29-0 99.75%
    C16-Dihydroceramide (N-Palmitoyl sphinganine) is an ester product.
    C16-Dihydroceramide
  • HY-W670044
    9-Oxooctadecanoic acid 4114-74-3
    9-Oxooctadecanoic acid (9-Oxostearic acid; 9-Ketostearic acid) is an ester product.
    9-Oxooctadecanoic acid
  • HY-W780142
    7-Hydroxy-3-oxo-Cholest-4-en-26-oic acid 115538-85-7 98.18%
    7-Hydroxy-3-oxo-Cholest-4-en-26-oic acid is an ester product.
    7-Hydroxy-3-oxo-Cholest-4-en-26-oic acid
  • HY-W923642
    Sphingomyelin (d18:1/12:0) 474923-21-2 99.0%
    Sphingomyelin (d18:1/12:0) is a metabolomic biomarker. Sphingomyelin (d18:1/12:0) exhibits favorable diagnostic properties and may facilitate the early detection and targeted prevention of dyslipidemia-related adverse cardiovascular events.
    Sphingomyelin (d18:1/12:0)
  • HY-W010452R
    3-Hydroxybutyric acid sodium (Standard) 150-83-4 99.74%
    3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutyric acid sodium (Standard)
  • HY-W012980R
    Isovaleric acid (Standard) 503-74-2 99.81%
    Isovaleric acid (Standard) is the analytical standard of Isovaleric acid. This product is intended for research and analytical applications. Isovaleric acid is an oral active short-chain fatty acid that inhibits osteoclast differentiation by stimulating AMPK phosphorylation and promotes colonic smooth muscle relaxation by activating the cAMP/PKA pathway. Isovaleric acid can be used in research on skeletal diseases (such as osteoporosis) and intestinal disorders.
    Isovaleric acid (Standard)
  • HY-W015061R
    Phenylacetylglycine (Standard) 500-98-1 99.38%
    Phenylacetylglycine (Standard) is the analytical standard of Phenylacetylglycine. This product is intended for research and analytical applications. Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.
    Phenylacetylglycine (Standard)
  • HY-W050145S
    Levoglucosan-d7 2483832-05-7 99.90%
    Levoglucosan-d7 is the deuterium labeled Levoglucosan. Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature.
    Levoglucosan-d7
  • HY-B0760S
    Fenofibric acid-d6 1092484-69-9 99.58%
    Fenofibric acid-d6 (FNF acid-d6) is the deuterium labeled Fenofibric acid. Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
    Fenofibric acid-d6
  • HY-12411
    AMG-3969 1361224-53-4 99.45%
    AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM.
    AMG-3969
  • HY-15566
    APD597 897732-93-3 99.97%
    APD597 (JNJ-38431055) is an orally active agonist of GPR119. APD597 exhibits reduced CYP2C9 inhibition with an IC50 of 5.8 μM. APD597 can be studied in research for type 2 diabetes.
    APD597
  • HY-15461A
    Ertugliflozin L-pyroglutamic acid 1210344-83-4 99.84%
    Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.
    Ertugliflozin L-pyroglutamic acid
Cat. No. Product Name / Synonyms Application Reactivity